NTVO - jaargang 20, nummer 5, oktober 2023
P.E. Borgonje , dr. G.J.M. Herder , dr. L.M. Andrews , dr. P. van Horssen , dr. J.M.H. de Klerk
In de PROFILE-studie wordt de radiotracer 68Ga-FAPI onderzocht bij patiënten met stadium IV niet-kleincellig longkanker. FAPI, ‘fibroblast activation protein inhibitor’, bindt zeer specifiek aan ‘fibroblast activation protein’ (FAP), dat tot expressie komt op het membraan van zogenoemde ‘cancer-associated fibroblasts’ (CAF’s). In verschillende typen kanker is aangetoond dat 68Ga-FAPI-PET/CT even goed of beter presteert dan 18F-FDG-PET/CT en in de PROFILE-studie zal dit specifiek bij niet-kleincellig longkanker verder worden onderzocht. Daarnaast wordt onderzocht of de 68Ga-FAPI-opname van voorspellende waarde kan zijn voor de respons op immuuntherapie.
(NED TIJDSCHR ONCOL 2023;20:215–7)
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